The cheapest flight a Medellín you can get by boooking 15 days before departure.
The most popular airlines on the route Quito - Medellín: Copa Airlines (CM), Avianca (AV), TAME (EQ).
The cheapest flights you can book on the route Mariscal Sucre (UIO) - José María Córdova (MDE).
There is no direct flight on the route desde Quito a Medellín
The shortest flights with change last about 3h 54min.